Car T Cell Therapy Side Effects

Cytokine release syndrome crs you may have heard of the cytokine storm in 2018 when many people got seriously ill during flu season.

Car t cell therapy side effects.

Car t cell therapy side effects. The most common side effects seen are. Because it s affecting your immune system car t can cause other changes in your body too. Low white blood.

As car t cells multiply they cause massive amounts of chemicals called cytokines to be released into the blood. When the modified t cells kill the tumor cells these then break into component parts and all the leftover gunk can be floating in your bloodstream. The possible side effects that your doctor will discuss with you include. This syndrome is caused when the transferred t cells or other immune cells responding to the new t cells release a large amount of cytokines into the blood.

These include neurotoxicity which can result in headache confusion and. The 133 participants in the fred hutch clinical trial believed to be the largest sample size in any published study of car t cell therapy side effects had advanced leukemias or lymphomas that had proven resistant to standard therapies. Cytokines are immune substances that have many different functions in the body. Car t cell therapy can cause a serious side effect known as cytokine release syndrome.

Car t cell therapy can trigger a range of side effects many of which begin subtly but can rapidly worsen. Some side effects can be severe or fatal. Despite the therapeutic successes of car t cell therapy the intervention carries the risk of severe side effects. Again tumor lysis is a side effect showing that the car t cell treatment is working perhaps too well.

Some people have had serious side effects from this treatment especially as the car t cells multiply in the body to fight the cancer. Cytokine release syndrome which is similar to flu like symptoms headache. Neurologic events can also be experienced and can be serious in some patients. Cytokine release syndrome crs.

Serious side effects of this release can include very high fevers and dangerously low blood pressure in the days after treatment is given. A potentially serious complication is cytokine release syndrome crs also known as a cytokine storm.